Release Profile

Designed for methylphenidate release
throughout the day1

Featuring multi-layer release beads and a biphasic pharmacokinetic profile, Adhansia XR combines attributes of an IR and ER in one capsule.1

IR=immediate release; ER=extended release.
Pharmacokinetic data do not correlate to clinical efficacy.

Watch how the multi-layer release (MLR™) technology works

Within the once-daily capsule, each bead releases the dose in two phases1-3

One methylphenidate dose is released immediately, and one is released later1-3

20 80 Percent
Multi-layer release beadMulti-layer release bead
Image is for illustrative purposes only.
Not shown in actual size or color.

Outermost
Layer

1

Methylphenidate HCl layer

  • Contains ~20% of the methylphenidate dose
  • Water-soluble (dissolves upon contact with GI fluid); designed for immediate release
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2

Delayed-release coating

  • pH dependent; dissolves when the GI environment pH is ≥7
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3

Controlled-release coating

  • Controlled-release polymer that becomes permeable in the GI tract
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4

Methylphenidate HCl layer

  • Contains ~80% of the methylphenidate dose, which gradually diffuses through the controlled-release polymer
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5

Sugar sphere

  • Core of the bead upon which ~80% of the methylphenidate dose is layered

Innermost
Layer

Biphasic release throughout your patients' day1,2

Adhansia XR produces an initial peak concentration, and a subsequent prolonged peak that tapers off thereafter1,2

Pharmacokinetic data do not correlate to clinical efficacy.

MEAN CONCENTRATION-TIME PROFILES FOR d,l-METHYLPHENIDATE ON DAY 5 (DAILY DOSING) IN ADULTS 18+ YEARS1,2*

PK Profile

Cmax=maximum plasma concentration.

*Evaluated in 21 healthy adults under fasted conditions for 5 consecutive days. Steady state achieved from Day 3.1,2

Median (range) times to 1st Cmax=1.5 (1-2.5) hours and 2nd Cmax=12 (8.5-16) hours.1,2

Adhansia XR contains a racemic mixture of d- and l‑methylphenidate.1,2